货号：04-593

品牌：Merck Millipore

规格：EA

目录价：￥3920.00

市场价格：￥3332.00

会员价格：￥3136.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAM1 (N-Term) Antibody, Rabbit, clone EP1042Y | 04-593 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse, Rat JAM1 (N-Term). View All» Immunogen: A synthetic peptide corresponding to residues near the N-terminus of human JAM1. View All» Clone: EP1042Y View All» Background Information: Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse, Rat (positive control: Hela cell lysate) View All» Application Notes: WB: 1:2000 IHC: 1:100 - 250 (Paraffin-embedded human liver) View All» Purification Method: Protein A purfied View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: Q9Y624 View All» Entrez Gene Number:
  • NM_144502.1

  • NM_144504.1

  • NM_016946.3

  • NM_144503.1
    View All» Gene Symbol:
    • F11R

    • JAM-A

    • PAM-1

    • JAMA

    • CD321

    • JAM

    • JAM1

    • JAM-1

    • JCAM

    • KAT
      View All» Alternate Names: Junctional Adhesion Molecule-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. View All» UniProt Summary: FUNCTION: SwissProt: Q9Y624 # Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation.SIZE: 299 amino acids; 32583 Da SUBUNIT: Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with the ninth PDZ domain of MPDZ.SUBCELLULAR LOCATION: Cell junction, tight junction; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.PTM: N-glycosylated.SIMILARITY: SwissProt: Q9Y624 ## Belongs to the immunoglobulin superfamily. & Contains 2 Ig-like V-type (immunoglobulin-like) domains. View All» Brand Family: Upstate View All» Product Name: Anti-JAM1 (N-Term) Antibody, Rabbit, clone EP1042Y | 04-593 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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