货号：MAB5380

品牌：Merck Millipore

规格：300UL

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Peripherin Antibody, clone 7C5 | MAB5380 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Peripherin, class III neuronal intermediate filament protein. By western blot, the antibody detects a band migrating at approximately 57 kDa corresponding to peripherin; reactive with human, bovine, porcine and rat peripherin by western blot, other species not tested. View All» Immunogen: Recombinant rat peripherin. View All» Clone: 7C5 View All» Isotype: IgG1κ View All» Background Information: Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems. Subsequently it was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. View All» Species Reactivity:

• Bovine

• Human

• Pig

• Rat
  View All» Application Notes: Immunocytochemistry 1:100. The integrity of the epitope recognized by this antibody is not affected by aldehyde-based fixatives as 8G2; light fixations are still preferred; not tested in paraffin embedded tissue sections. Immunoblotting 1:1,000; 57kDa Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Sensory neurons of the central or peripheral nervous system; PC12 cells View All» Presentation: Purified immunoglobulin in PBS containing no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P41219 View All» Entrez Gene Number: NM_006262.3 View All» Gene Symbol:
  • PRPH

  • PRPH1

  • Peripherin.

  • peripherin

  • NEF4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. View All» UniProt Summary: FUNCTION: SwissProt: P41219 # Class-III neuronal intermediate filament protein.SIZE: 470 amino acids; 53651 Da SIMILARITY: SwissProt: P41219 ## Belongs to the intermediate filament family. View All» Brand Family: Chemicon View All» Product Name: Anti-Peripherin Antibody, clone 7C5 | MAB5380 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 300 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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