货号：04-787

品牌：Merck Millipore

规格：100UL

目录价：￥3697.00

市场价格：￥3142.45

会员价格：￥2957.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PKD (Ser916) Antibody, clone MC29 | 04-787 View All» Replaces: 05-787 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Trade Name: Upstate (Millipore) View All» Specificity: phospho-PKD View All» Molecular Weight: ~105-110kDa View All» Immunogen: peptide containing RVpSIL in which pS corresponds to phospho-serine 916 of mouse PKD View All» Modifications: Phosphorylation View All» Clone: MC29 View All» Isotype: IgG View All» Background Information: There are two PKD isoforms (PKD1 and PKD2) belonging to the polycystin family. These proteins are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. Defects in PKD1 have been identified as the cause of autosomal dominant polycystic kidney disease type I (ADPKD). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human. Predicted to cross-react with mouse based on sequence homology. View All» Application Notes: Western Blot Analysis: 1:500-1:2000 of this lot detected PKD in RIPA lysates from HEK293 cells stimulated with phorbol 12,13-dibutyrate (PDBu) for 10 minutes at 50 ng/mL. View All» Control: RIPA lysates from HEK293 cells View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HEK293 cells stimulated with phorbol 12,13-dibutyrate View All» Presentation: Cultured supernantant in 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: Q15139 View All» Entrez Gene Number: NM_002742 View All» Gene Symbol:
  • PRKD1

  • PKD

  • PKCM

  • nPKC-mu

  • PRKCM

  • PKC-mu

  • nPKC-D1

  • PKC-MU

  • PKD1
    View All» Alternate Names:
    • Protein kinase C mu type

    • Protein kinase D

    • polycystic kidney disease 1 (autosomal dominant)

    • polycystic kidney disease-associated protein

    • polycystin 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated signal transduction pathways. See PRKCA (MIM 176960) for further background information. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q15139 # This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.SIZE: 912 amino acids; 101888 Da SUBUNIT: Interacts via its N-terminal region with CENTA1.PTM: Autophosphorylated (By similarity).SIMILARITY: SwissProt: Q15139 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 PH domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PKD (Ser916), clone MC29 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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