货号：04-886

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W | 04-886 View All» Replaces: 05-886 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Phospho-STAT5A/B (Tyr694/699). View All» Molecular Weight: ~95 kDa View All» Epitope: pTyr694/699 View All» Immunogen: KLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B. View All» Modifications: Phosphorylation View All» Clone: A11W View All» Isotype: IgG View All» Background Information: The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation. View All» Species Reactivity:

• Rat

• Human

• Mouse

• Bovine

• Chimpanzee
  View All» Applications Not Recommended: Immunoprecipitation View All» Control: PDGF treated 3T3/NIH cells View All» Quality Assurance: Evaluated by western blot on RIPA lysates from 3T3/NIH cells untreated and treated with PDGF.Western Blot Analysis:A 1:1,000-1:2,000 dilution of this antibody detected phospho-STAT5A/B (Tyr694/699) in lysates from 3T3/NIH cells treated with PDGF. View All» Presentation: Cultured supernatant containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P42229 View All» Entrez Gene Number: NM_003152 (STAT5A), NM_012448 (STAT5B) View All» Gene Symbol:
  • MGF

  • STAT5

  • STAT5
    View All» Alternate Names:
    • signal transducer and activator of transcription 5A

    • signal transducer and activator of transcription 5B

    • transcription factor STAT5B
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq] View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 By similarity. Interacts with NCOA1 and SOCS7.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note= Translocated into the nucleus in response to phosphorylation.PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity By similarity.SIMILARITY: Belongs to the transcription factor STAT family.Contains 1 SH2 domain. View All» Product Name: Anti-phospho-STAT5A/B (Tyr694/699), clone A11W View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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