货号：MAB5542

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Prion Protein Antibody, clone 2G11 | MAB5542 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # MAB5542 recognizes the C-terminus of Prion Protein. View All» Molecular Weight: ~27 kDa View All» Epitope: C-terminus View All» Immunogen: KLH conjugated synthetic linear peptide corresponding to the C-terminus. View All» Clone: 2G11 View All» Isotype: IgG2aκ View All» Background Information: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. View All» Species Reactivity:

• Rat

• Human

• Sheep

• Mouse
  View All» Species Reactivity Note: Rat. May react with Mouse, Sheep (See References) and Human based on sequence homology. Reactivity with other species has not been determined. View All» Application Notes: Immunohistochemistry: 1:50-1:300 working dilutions of anti-Prion Protein, clone 2G11 localizes prion protein in rat brain paraffin embedded tissue. View All» Control: Rat brain tissue lysate. View All» Quality Assurance: Western Blot: A 1 mg/mL dilution of this antibody was used to detect anti-Prion Protein, clone 2G11 View All» Purification Method: Protein G purfied View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P23907 View All» Entrez Gene Number: NM_000311.3 View All» Gene Symbol:
  • ASCR

  • CD230

  • CJD

  • GSS

  • MGC26679

  • OTTHUMP00000030162

  • OTTHUMP00000030163

  • PRIP

  • PRP

  • PrP

  • PrP27-30

  • PrP33-35C

  • PrPc

  • p27-30

  • prion
    View All» Alternate Names:
    • CD230 antigen

    • major prion protein

    • prion protein

    • prion protein (p27-30)

    • prion protein PrP

    • prion-related protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq] View All» UniProt Summary: FUNCTION: The function of PrP is not known. PrP is encoded in the host genome and is expressed both in normal and infected cells.SUBUNIT STRUCTURE: PrP has a tendency to aggregate yielding polymers called "rods". Component of a epididymal complex at least composed of soluble form of prion protein PRNP, CLU, BPI, EST7, MANBA and GLB1. Interacts with GRB2, PRNPIP and SYN1 By similarity.SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor › GPI-anchor. Golgi apparatusBy similarity. DISEASE: Polymorphism at position 171 may be related to the alleles of scrapie incubation-control (SIC) gene in this species.Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.Scrapie is a transmissible neurodegenerative disorder of sheep and goats. Most sheep that contract the disease naturally die between 24 and 50 months of age. The incubation period in sheep depends on the strain(s) of the infecting pathogen, sheep age at exposure, and the sheep genotype. The survival time is mainly determined by a single genetic locus, SIP, which has two alleles, susceptible (sa) and resistant (pa). Short incubation period is conferred by the partially dominant sa allele. Scrapie can be spread between flockmates, or it can be transmitted from an infected ewe to its lamb.SIMILARITY: Belongs to the prion family. View All» Product Name: Anti-Prion Protein, clone 2G11 View All» Concentration: 1 mg/mL. View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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