货号：MAB5550

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TorsinA Antibody | MAB5550 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: TorsinA View All» Molecular Weight: 37kDa View All» Immunogen: Maltose binding protein fusion protein from human torsinA. View All» Isotype: IgG1 View All» Background Information: TorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: Positive Control: Human brain lysate, NGF treated PC12 cells. View All» Purification Method: Ascites View All» Presentation: Liquid. Contaings no preservative View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O14656 View All» Entrez Gene Number: NM_000113.2 View All» Gene Symbol:
  • TOR1A

  • DQ1

  • DYT1

  • TOR1B

  • DQ2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. View All» UniProt Summary: FUNCTION: SwissProt: O14656 # May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.SIZE: 332 amino acids; 37809 Da SUBUNIT: Interacts with TOR1AIP1 and TOR1AIP2.SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. Also found associated with the nuclear envelope. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum.TISSUE SPECIFICITY: Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord.DISEASE: SwissProt: O14656 # Defects in TOR1A are the cause of torsion dystonia 1 (DYT1) [MIM:128100]; also known as primary or idiopathic dystonia. This autosomal dominant disorder is the most common and severe type of dystonia manifesting itself as sustained muscle contractions inducing twisting and repetitive movements and/or abnormal posture. Symptoms usually begin in the arms or legs at a mean age of 12 years and progress to other body parts within 5 years.SIMILARITY: SwissProt: O14656 ## Belongs to the clpA/clpB family. Torsin subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-TorsinA Antibody | MAB5550 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic, ER View All» Format: Ascites View All» Host: Mouse View All»
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