货号：04-959

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 | 04-959 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~52 kDa observed View All» Epitope: Unknown View All» Immunogen: Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT). View All» Clone: RORg2 View All» Background Information: Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: EL4 cell lysate View All» Quality Assurance: Evaluated by Western Blot in EL4 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51450 View All» Entrez Gene Number: NP_035411 View All» Gene Symbol:

• RORG

• RZRG

• NR1F3

• RORC

• TOR
  View All» Alternate Names:
  • RAR-related orphan receptor C

  • RAR-related orphan receptor gamma

  • retinoic acid-binding receptor gamma

  • nuclear receptor ROR-gamma

  • retinoid-related orphan receptor gamma

  • Nuclear receptor RZR-gamma

  • RZR-GAMMA

  • Nuclear receptor subfamily 1 group F member 3

  • RAR-related orphan receptor C, isoform a

  • Retinoid-related orphan receptor-gamma
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow. SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. View All» Product Name: Anti-Retinoid-Related Orphan Receptor γ T, clone RORg2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Armenian Hamster View All»
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