货号：04-960

品牌：Merck Millipore

规格：EA

目录价：￥3144.00

市场价格：￥2672.40

会员价格：￥2515.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FOXP3 Antibody, clone 3G3 | 04-960 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of Forkhead box protein P3 (FOXP3). View All» Molecular Weight: Expected molecular weight ~47 kDa.On western blot, a molecular weight of ~49-55 kDa may be observed (Bolzer, K., et al., 2009). View All» Epitope: N-terminus View All» Immunogen: Histadine-tagged recombinant protein corresponding to the N-terminus of mouse FOXP3. View All» Isotype: IgG1κ View All» Background Information: The regulation of tolerance to self-antigens is a necessary biological process in order to prevent autoimmunity. CD4+ CD25+ regulatory T cells are known regulators of immune tolerance and activation. In both human and mice species, CD4+ CD25+ regulatory T cells are consistent in their expression of the transcription factor FOXP3 (forkhead box P3). FOXP3 acts as the “master switch” for the function and development of regulatory T cells. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, recent studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Flow Cytometry Analysis: 1 µg from a previous lot of a biotinylated version of this antibody detected FOXP3 in human PBMC's. THIS ANTIBODY IS NOT BIOTINYLATED.ELISA: A previous lot of this antibody was shown to work in ELISA by an independent laboratory (Gavin, M., et al., 2006). View All» Control: Mouse CD4+ CD25+ splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in mouse CD4+ CD25+ splenocytes.Flow Cytometry Analysis: 5 µg of a biotinylated version of this antibody detected FOXP3 in mouse CD4+ CD25+ splenocytes.THIS ANTIBODY IS NOT BIOTINYLATED. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q99JB6 View All» Entrez Gene Number: NP_473380 View All» Gene Symbol:
  • FOXP3

  • AIID

  • DIETER

  • IPEX

  • JM2

  • PIDX

  • SCURFIN

  • Scurfin

  • XPID

  • scurfin
    View All» Alternate Names:
    • forkhead box P3

    • immune dysregulation, polyendocrinopathy, enteropathy, X-linked

    • immunodeficiency, polyendocrinopathy, enteropathy, X-linked
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • ELISA
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: Probable transcription factor. Plays a critical role in the control of immune response.SUBCELLULAR LOCATION: Nucleus Potential. TISSUE SPECIFICITY: High level of expression in thymus and spleen.INVOLVEMENT IN DISEASE: Defects in Foxp3 are the cause of the scurfy phenotype (sf). It results in a lethal disorder of immunoregulation, characterized by infections, diarrhea, anemia, thrombocytopenia, hypogonadism, gastrointestinal bleeding, lymphadenopathy and leukocytosis.SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-FOXP3, clone 3G3 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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