货号：04-961

品牌：Merck Millipore

规格：EA

目录价：￥3084.00

市场价格：￥2621.40

会员价格：￥2467.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 12 (IL-12) Antibody, clone 8.6 | 04-961 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IL-12, subunit p40. View All» Molecular Weight: ~37 kDa View All» Epitope: Unknown View All» Immunogen: Purified human IL-12, p40 subunit. View All» Clone: 8.6 View All» Isotype: IgG1κ View All» Background Information: Interleukin 12 (IL-12) is an interleukin produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) and is involved in the differentiation of naive T cells into Th1 cells or Th2 cells. IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits and is considered a T cell stimulating factor. IL-12 stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T and natural killer (NK) cells and reduces IL-4 mediated suppression of IFN-γ. IL-12 can also block the formation of new blood vessels through its induction cascade and is a possible target for anti-cancer drug screening. IL-12 may play a role in autoimmunity by worsening the autoimmune response, due to its key role in induction of Th1 immune responses. Whereas, IL-12 gene knock-out in mice or a treatment of mice with IL-12 specific antibodies seems to ameliorate the diseases. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HiCK-3 Cytokine Positive Cells View All» Quality Assurance: Evaluated by Flow Cytometry in HiCK-3 Cytokine Positive Cells.Flow Cytometry Analysis: A 1:100 dilution of this antibody detected IL-12 in HiCK-3 Cytokine Positive Cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P29460 View All» Entrez Gene Number: NP_002178 View All» Gene Symbol:

• IL12B

• CLMF

• CLMF2

• IL-12B

• NKSF

• NKSF2
  View All» Alternate Names:
  • CLMF p40

  • Cytotoxic lymphocyte maturation factor 40 kDa subunit

  • IL-12 subunit p40

  • IL12, subunit p40

  • NK cell stimulatory factor chain 2

  • interleukin 12, p40

  • interleukin 12B

  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

  • interleukin-12 beta chain

  • natural killer cell stimulatory factor, 40 kD subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. SUBUNIT STRUCTURE: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. SUBCELLULAR LOCATION: Secreted. PTM: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.INVOLVEMENT IN DISEASE: Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain. View All» Product Name: Anti-Interleukin 12 (IL-12), clone 8.6 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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