货号：04-964

品牌：Merck Millipore

规格：

目录价：￥3323.00

市场价格：￥2824.55

会员价格：￥2658.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 4 (IL-4) Antibody, clone 11.B.11 | 04-964 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IL-4. View All» Molecular Weight: ~ 15 kDa View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to mouse IL-4. View All» Clone: 11B11 View All» Isotype: IgG1κ View All» Background Information: Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Functional Activity Assay: A previous lot was utilized by an independent laboratory to show increased resistance of mice to Listeria monocytogenes infection after administration of anti-interleukin 4 (IL-4), clone 11.B.11. (Haak-Frendscho, M., et al., 1992). View All» Control: MiCK-2™ cells View All» Quality Assurance: Evaluated by Flow Cytometry in MiCK-2™ cells.Flow Cytometry Analysis: 10 µg of this antibody detected IL-4 in MiCK-2™ cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07750 View All» Entrez Gene Number: NP_067258.1 View All» Gene Symbol:

• IL4

• Binetrakin

• Pitrakinra

• BSF1

• BSF-1

• IL-4
  View All» Alternate Names:
  • B cell growth factor 1

  • B-cell stimulatory factor 1

  • B_cell stimulatory factor 1

  • Lymphocyte stimulatory factor 1

  • interleukin 4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Enzyme Assay
      View All» UniProt Summary: FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.SUBCELLULAR LOCATION: Secreted. SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family. View All» Product Name: Anti-Interleukin 4 (IL-4), clone 11.B.11 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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