货号：MAB5586

品牌：Merck Millipore

规格：50Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cyclooxygenase-1 Antibody | MAB5586 View All» Replaces: AB5116 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Cyclooxygenase 1 (Cox-1). View All» Immunogen: Purified Sheep Cox-1. View All» Species Reactivity:

• Human

• Bovine

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:200-1:2,000 using ECL. The antibody reacts with the ~70 kDa protein in uninduced NIH/3T3 cells (2). Immunohistochemistry: not tested. It is suggested that the antibody be tried at 5-10 μg/mL. ELISA: 1,10,000-1:30,000. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5 with 0.05% sodium azide. View All» Storage Conditions: Maintain -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P23219 View All» Entrez Gene Number:
  • NM_000962.2

  • NM_080591.1
    View All» Gene Symbol:
    • PTGS1

    • PCOX1

    • PGHS1

    • COX-1

    • PGHS-1

    • PGG/HS

    • PHS1

    • COX1

    • PTGHS

    • COX3

    • EC 1.14.99.1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • ELISA
        View All» Entrez Gene Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. View All» UniProt Summary: FUNCTION: SwissProt: P23219 # May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).SIZE: 599 amino acids; 68656 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein.SIMILARITY: SwissProt: P23219 ## Belongs to the prostaglandin G/H synthase family. & Contains 1 EGF-like domain. MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase. & This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin. View All» Brand Family: Chemicon View All» Product Name: Anti-Cyclooxygenase-1 Antibody | MAB5586 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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