货号：04-970

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Osteopontin Antibody, clone 6B6.2 | 04-970 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Osteopontin at the C-terminus. View All» Molecular Weight: ~70 kDa observed. The calculated molecular weight of this protein is ~35 kDa but it is has extensive post transitional modifications and runs at ~70 kDa. (Adhikari, N., et al. (2010). Arterioscler Thromb Vasc Biol. 31(1):86-94.) View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Osteopontin. View All» Clone: 6B6.2 View All» Isotype: IgMκ View All» Background Information: Osteopontin is a single-chain polypeptide. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of osteopontin in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in osteopontin "knockout" mice has not established a definitive role for osteopontin in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of osteopontin to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected Osteopontin on 10 µg of mouse kidney lysate. View All» Control: Human serum lysate View All» Quality Assurance: Evaluated by Western Blot in human serum lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Osteopontin on 10 µg of human serum lysate. View All» Purification Method: Ion Exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P10451 View All» Entrez Gene Number: NP_000573 View All» Gene Symbol:
  • BNSP

  • BSPI

  • ETA-1

  • Nephropontin

  • OPN

  • SPP-1
    View All» Alternate Names:
    • Bone sialoprotein 1

    • SPP1/CALPHA1 fusion

    • Urinary stone protein

    • bone sialoprotein I

    • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein

    • secreted phosphoprotein 1

    • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

    • secreted phosphoprotein-1 (osteopontin, bone sialoprotein)

    • Uropontin

    • osteopontin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).SUBUNIT STRUCTURE: Ligand for integrin alpha-V/beta-3.SUBCELLULAR LOCATION: Secreted. PTM: Extensively phosphorylated on clustered serine residues. N- and O-glycosylated. DISEASE: This protein plays a principal role in urinary stone formation as the stone matrix.SEQUENCE SIMILARITY: Belongs to the osteopontin family. View All» Product Name: Anti-Osteopontin, clone 6B6.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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