货号：MAB5594

品牌：Merck Millipore

规格：

目录价：￥3730.00

市场价格：￥3170.50

会员价格：￥2984.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HCN1 Antibody, clone RQT 7C3 | MAB5594 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: HCN1 (Hyperpolarization-activated and cyclic nucleotide-gated channel 1). The antibody recognizes both the glycosyated and deglycosylated form of HCN1. View All» Molecular Weight: 102 kDa View All» Epitope: C-Terminus View All» Immunogen: Synthetic peptide from rat HCN1. View All» Clone: RQT 7C3 View All» Isotype: IgG1 View All» Background Information: HCN1 and HCN2 play an important role for motor learning and synapse formation by integration of cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is high in the cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN channels contain a GYG motif in the pore. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse and Rat. Reactivity with other species has not been determined. View All» Application Notes: Western blot on rat and mouse retina. The antibody recognizes the ~110 kDa glycosylated protein from a retinal membrane preparation. Immunohistochemistry on rat and mouse retina. Optimal working dilutions must be determined by end user. View All» Control: Mouse Brain Lysate View All» Quality Assurance: Routinely evaluated by western blot on mouse brain lysate. View All» Purification Method: PBS View All» Presentation: Purified in PBS with 0.05% NaN3 View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9JKB0 View All» Entrez Gene Number: NM_021072.2 View All» Gene Symbol:
  • HCN1

  • BCNG1

  • BCNG-1

  • HAC-2
    View All» Alternate Names: Hyperpolarization-activated and cyclic nucleotide-gated channel 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP (By similarity). May mediate responses to sour stimuli. SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN2 (By similarity). Interacts with KCNE2 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in cerebral cortex, cerebellum, throughout the hippocampus, in medial habenula, anterior dorsal nucleus in the thalamus, tenia tecta, several nuclei of the general motor system and in optic nerve layer. Detected in a subset of elongated cells in taste buds. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel HCN family. SIMILARITY: Contains 1 cyclic nucleotide-binding domain. View All» Product Name: Anti-HCN1, clone RQT 7C3 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Rat View All»
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