货号：MAB5680

品牌：Merck Millipore

规格：100Ug

目录价：￥7049.00

市场价格：￥5991.65

会员价格：￥5639.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody | MAB5680 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Membane associated region of MOG [Myelin oligodendrocyte glycoprotein]. View All» Molecular Weight: 28 kDa View All» Epitope: The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG. View All» Immunogen: Rat cerebellar glycoproteins View All» Clone: 8-18C5 View All» Isotype: IgG1 View All» Background Information: Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: May cross react with human and bovine based on sequence similarity. View All» Control: brain lysate View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Purified immunoglobulin View All» Presentation: Purified in PBS with 0.05% NaN₃. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: Q63345 View All» Entrez Gene Number: M99485.1 View All» Alternate Names: MOG View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunocytochemistry

  • Immunohistochemistry

  • Western Blotting
    View All» UniProt Summary: FUNCTION: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. SUBUNIT: May form homodimers. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination. SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG). View All» Brand Family: Chemicon View All» Product Name: Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody | MAB5680 View All» Concentration: See Certificate of Analysis View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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