货号：MAB5768

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chromogranin A Antibody, clone 2B9.2 | MAB5768 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 68 kDa View All» Immunogen: Peptide View All» Clone: 2B9.2 View All» Isotype: IgG1 View All» Background Information: Chromogranin A is the major member of the granin family of acidic secretory glycoproteins that are expressed in all endocrine and neuroendocrine cells. The granins have been proposed to play multiple roles in the secretory process. Intracellularly, granins play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathway by virtue of their ability to aggregate in the low-pH, high-calcium environment of the trans-Golgi network (1). View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein G purfied View All» Presentation: 1 x PBS containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 2-8°C from date of shipment View All» UniProt Number: P10645 View All» Entrez Gene Number: NM_001275.3 View All» Gene Symbol:

• CHGA

• CgA

• SP-I

• CGA
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. View All» UniProt Summary: FUNCTION: SwissProt: P10645 # Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.SIZE: 457 amino acids; 50730 Da SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine secretory granules.PTM: Sulfated on tyrosine residues and/or contains sulfated glycans.SIMILARITY: SwissProt: P10645 ## Belongs to the chromogranin/secretogranin protein family. MISCELLANEOUS: Binds calcium with a low-affinity. View All» Brand Family: Chemicon View All» Product Name: Anti-Chromogranin A Antibody, clone 2B9.2 | MAB5768 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 mL View All» Target / Localization: Peripheral, Neuroendocrine, presynaptic View All» Format: Purified View All» Host: Mouse View All»
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