货号：MAB6021

品牌：Merck Millipore

规格：500UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome P450 Aldosterone Synthase Antibody, clone 1G5 | MAB6021 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Rat cytochrome p450 aldosterone synthase View All» Immunogen: Aldo-1-MAP (aa 175-192) (KVRQNARGSLTMDVQQSL-MAP) View All» Clone: 1G5 View All» Isotype: IgG1κ View All» Background Information: Aldosterone synthase (or 18-hydroxylase) is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. (Pascoe, L, et al. (1992) "Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency." PNAS, USA. 89:496-5000). View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: recognizes ~48kDa band in adrenal zona glomerulosa mitochondrial preparations. The enzyme is expressed best in adrenal zona glomerulosa tissues, expression in kidney is virtually undetectable.Immunohistochemistry: 1:50-1:200 , ABC, enzymatic detection; clone works best with STF fixed tissues that are paraffin embedded. STF is available from Streck Laboratories, www.streck.com. Formalin fixation has been successfully reported but working dilutions are much lower (see Fujisawa, et al). Recommended counter stain is Gill's Haematoxylin.Immunocytochemistry: acetone fixed cells, 1:20-1:200.ELISAOptimal working dilutions must be determined by end user. View All» Presentation: Unpurified tissue culture supernatant containing 50% glycerol and 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P30099 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunocytochemistry

  • Immunohistochemistry (Paraffin)

  • Western Blotting
    View All» Brand Family: Chemicon View All» Product Name: Anti-Cytochrome P450 Aldosterone Synthase Antibody, clone 1G5 | MAB6021 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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