货号：05-1058

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-CRKL (Tyr207) Antibody, clone 7.124.12 | 05-1058 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Reacts with phosphorylated human CRKL . View All» Molecular Weight: ~39 kDa View All» Epitope: Phosphorylated Tyr207 View All» Immunogen: KLH-conjugated synthetic peptide surrounding phosporykated tyrosine amino acid 207 of human CRKL. View All» Modifications: Phosphorylation View All» Clone: clone 7.124.12 View All» Isotype: IgG View All» Background Information: CRKL is a 39 kDa adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with human. Predicted to cross react with mouse and rat, based on 100% sequence homology. Reactivity with other species has not been tested. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated on a representative lot by Western blot in K562 cell lysates. View All» Presentation: Supernatant containing 0.05% NaN3. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P46109 View All» Entrez Gene Number: P46109 View All» Alternate Names:
  • v-crk avian sarcoma virus CT10 oncogene homolog-like

  • v-crk sarcoma virus CT10 oncogene homolog (avian)-like
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May mediate the transduction of intracellular signals.SUBUNIT STRUCTURE: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4. SEQUENCE SIMILARITIES: Contains 1 SH2 domain.Contains 2 SH3 domains. View All» Product Name: Anti-phospho-CRKL (Tyr207), clone 7.124.12 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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