货号：05-1075

品牌：Merck Millipore

规格：200Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FOXO1 Antibody, clone 2H8.2 | 05-1075 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects FOXO1. FOXO1 shuttles between the nucleus and the cytosol. View All» Molecular Weight: ~78-82 kDa View All» Immunogen: GST-tagged recombinant protein corresponding to full length FOXO1. View All» Clone: 2H8.2 View All» Isotype: IgG1κ View All» Background Information: Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Gross, D.N., 2009). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse and rat. View All» Application Notes: Immunocytochemistry: A 1:500 dilution of a previous lot was used. Immunocytochemistry: Representative lot data.A 1:500 dilution of a previous lot was used. Immunohistochemistry (Paraffin): Representative lot data.Optimal Staining With Epitope Retrieval: Ductal Carcinoma In Situ. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by western blot on HEK293 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected FOXO1 in HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q12778 View All» Entrez Gene Number: NP_002006.2 View All» Gene Symbol:
  • FKH1

  • FKHR

  • FOXO1A

  • OTTHUMP00000018301
    View All» Alternate Names:
    • Forkhead box protein O1A

    • Forkhead in rhabdomyosarcoma

    • forkhead box O1

    • forkhead box O1A (rhabdomyosarcoma)

    • forkhead homolog in rhabdomyosarcoma

    • forkhead, Drosophila, homolog of, in rhabdomyosarcoma
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Transcription factor. SUBUNIT STRUCTURE: Interacts with LRPPRC By similarity.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Shuttles between cytoplasm and nucleus. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated by AKT1; insulin-induced By similarity. IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.INVOLVEMENT IN DISEASE: Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-FOXO1, clone 2H8.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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