货号：05-1139

品牌：Merck Millipore

规格：100Ug

目录价：￥5569.00

市场价格：￥4733.65

会员价格：￥4455.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Focal Adhesion Kinase Antibody, clone BLAb2H7 | 05-1139 View All» Replaces: MAB2156 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Focal Adhesion Kinase View All» Molecular Weight: ~125 kDa View All» Epitope: Terminal View All» Immunogen: Recombinant fragment derived from the amino terminal region of chicken FAK, amino acid residues 103 to 553. View All» Clone: BLAb2H7 View All» Isotype: IgG1 View All» Background Information: FAK is a 125 Kd protein that is recruited as a participant in focal adhesion dynamics between cells and has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src (Guan, J L and Shalloway, D). This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival. FAK is typically located at structures known as focal adhesions, these are multi-protein structures that link the extracellular matrix (ECM) to the cytoplasmic cytoskeleton. Additional components of focal adhesions include actin, filamin, vinculin, talin, paxillin and tensin (Burridge, K, et al). View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chicken
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, rat and chicken. View All» Application Notes: Immunohistochemistry Analysis: A previous lot detected Focal Adhesion Kinase at 1:100 dilution in mouse cortex tissue. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blotting in HEK293 cell lysate.Western Blotting Analysis: 0.2 µg/mL of this antibody detected Focal Adhesion Kinase in 10 µg of HEK293 cell lysate. View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q05397 View All» Entrez Gene Number: NP_990766.1 View All» Gene Symbol:
  • EC 2.7.10.2

  • FADK

  • FAK

  • FAK1

  • pp125FAK
    View All» Alternate Names:
    • FADK 1

    • PTK2 protein tyrosine kinase 2

    • Protein-tyrosine kinase 2

    • focal adhesion kinase 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SUBUNIT STRUCTURE: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with RGNEF and SHB By similarity. Interacts with TGFB1I1 and STEAP4. SUBCELLULAR LOCATION: Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Constituent of focal adhesions.TISSUE SPECIFICITY: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain. DOMAIN: The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL By similarity.The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.PTM: Phosphorylated on 6 tyrosine residues upon activation. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain. View All» Product Name: Anti-Focal Adhesion Kinase, clone BLAb2H7 View All» Concentration: 0.1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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