货号：05-1144

品牌：Merck Millipore

规格：100Ug

目录价：￥4368.00

市场价格：￥3712.80

会员价格：￥3494.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Talin Antibody, C-terminus, clone TD77 | 05-1144 View All» Replaces: MAB3264 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes Human Talin, and cross reacts with Mouse and chicken Talin. The epitope recognized by this antibody is located within the C-terminal region of the protein (residues 2269-2541), which also contains an F-actin binding site homologous to that in the yeast actin-binding protein SIa2p. View All» Molecular Weight: 270 kDa View All» Epitope: C-terminus View All» Immunogen: Human platelet protein View All» Clone: TD77 View All» Isotype: IgG1 View All» Background Information: Talin consisting of a 47-kDa N-terminal head domain (residues 1-433) and a 190-kDa C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton. View All» Species Reactivity:

• Human

• Chicken

• Mouse
  View All» Species Reactivity Note: Proven to react with human. Expected cross-reactivity in mouse and chicken. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Talin in human GI track tissue. View All» Control: Jurkat cell lysate. View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysates.Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates. View All» Purification Method: Purified from Protein A Sepharose™ chromatography View All» Presentation: Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PBS pH 7.6, 0.25 M NaCl containing 0.1% sodium azide. View All» Storage Conditions: Maintain between 2 and 8°C for 1 year after date of receipt. View All» UniProt Number: Q9Y490 View All» Entrez Gene Number: Q9Y490 View All» Gene Symbol:
  • ILWEQ

  • KIAA1027

  • TLN
    View All» Alternate Names: talin 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts By similarity.SUBUNIT STRUCTURE: Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. SUBCELLULAR LOCATION: Cell projection › ruffle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton By similarity. Note: Colocalizes with LAYN at the membrane ruffles By similarity.SEQUENCE SIMILARITIES: Contains 1 FERM domain.Contains 1 I/LWEQ domain. View All» Product Name: Anti-Talin, C-terminus, clone TD77 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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