货号：05-1238

品牌：Merck Millipore

规格：

目录价：￥3789.00

市场价格：￥3220.65

会员价格：￥3031.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PARN Antibody, clone 7A7.1 | 05-1238 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~80 kDa observed View All» Immunogen: Linear peptide corresponding to human PARN. View All» Clone: 7A7.1 View All» Isotype: IgMκ View All» Background Information: Poly(A) ribonuclease (PARN) is a exoribonuclease responsible for the deadenylation of mRNA. This protein is constitutively expressed in virtually all mammalian tissues. With a critical role in the post-transcriptional control of gene expression PARN consists of two RNA-binding domains and one catalytic domain. Although PARN has a preference for poly(A), data suggests the protein can also degrade poly(U). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected PARN, clone 7A7.1 in HeLa cells. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PARN on 10 µg of A431 cell lysate. View All» Purification Method: Ion exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95453 View All» Entrez Gene Number: NP_002573 View All» Gene Symbol:

• PARN

• DAN
  View All» Alternate Names:
  • Poly(A)-specific ribonuclease PARN

  • Deadenylating nuclease

  • Deadenylation nuclease

  • Polyadenylate-specific ribonuclease
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.CATALYTIC SCTIVITY: Exonucleolytic cleavage of poly(A) to 5'-AMP.COFACTOR: Divalent metal cations. Mg2+ is the most probable.SUBUNIT STRUCTURE: Homodimer. Interacts with KHSRP and CELF1/CUGBP1. Found in a mRNA decay complex with RENT1, RENT2 and RENT3B.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Nucleus › nucleolus. Note: Some nuclear fraction is nucleolar.TISSUE SPECIFICITY: Ubiquitous.SEQUENCE SIMILARITIES: Belongs to the CAF1 family. Contains 1 R3H domain. View All» Product Name: Anti-PARN, clone 7A7.1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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