货号：05-1322

品牌：Merck Millipore

规格：

目录价：￥4633.00

市场价格：￥3938.05

会员价格：￥3706.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bmi-1 Antibody, clone DC9 | 05-1322 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes murine BMI-1 (~35 kDa). View All» Molecular Weight: approx. 35 kDa View All» Immunogen: Recombinant fusion protein of full length murine BMI-1 tagged with MBP. View All» Clone: DC9 View All» Isotype: IgG1κ View All» Background Information: The Bmi-1 protein is a member of the polycomb group (PcG) proteins. Bmi-1 has been reported as an oncogene by regulating the cell cycle inhibitors p16 and p19. Bmi-1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi-1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. Bmi-1 may regulate the self-renewal of other types of somatic stem cells, and it is also thought to inhibit aging in neurons through the suppression of p53. Several lines of evidence implicate Bmi-1 in tumorigenesis. Differential expression of Bmi-1 in a mouse model of metastatic prostate cancer vs. wild-type suggests Bmi-1 expression levels may predict response to therapy and survival in multiple types of cancer. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse. Not tested in other species. View All» Application Notes: Immunoprecipitation: This antibody has been demonstrated by an outside laboratory to be suitable for immunoprecipitation1. View All» Control: U20S Cell Lysate View All» Quality Assurance: Routinely evaluated by Western Blot on U20S cell lysate.Western Blot Analysis: 1:5,000 of this lot detected BMI-1 on 15 μg/mL of U20S cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Mouse monoclonal IgG1κ ascites in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P35226 View All» Entrez Gene Number: NP_031578.2 View All» Gene Symbol:
  • MGC12685

  • PCGF4

  • RNF51

  • flvi-2/bmi-1
    View All» Alternate Names:
    • B lymphoma Mo-MLV insertion region 1 homolog

    • B lymphoma Mo-MLV insertion region 1 homolog (mouse)

    • BMI1 polycomb ring finger oncogene

    • Polycomb group RING finger protein 4

    • RING finger protein 51

    • murine leukemia viral (bmi-1) oncogene homolog

    • oncogene BMI-1

    • polycomb group ring finger 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Ref.8 Ref.11SUBUNIT STRUCTURE: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Ref.11 Ref.4 Ref.5 Ref.7 Ref.9SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Ref.11PTM: May be polyubiquitinated; which does not lead to proteasomal degradation.DISEASE: Cooperates with the MYC oncogene to produce B-lymphomas.SIMILARITY: Contains 1 RING-type zinc finger. View All» Product Name: Anti-Bmi-1, clone DC9 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Ascites View All» Host: Mouse View All»
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