货号：05-1324

品牌：Merck Millipore

规格：200UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Histone H1 Antibody, clone 12D11 | 05-1324 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes phosphorylated Histone H1, Mr 32 kDa. View All» Molecular Weight: ~32 kDa View All» Immunogen: The immunogen was KLH-conjugated bovine nuclear extract. View All» Modifications: Phosphorylation View All» Clone: 12D11 View All» Isotype: IgMκ View All» Background Information: Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into 30nm chromatin fibers and higher order structures. View All» Species Reactivity:

• Human

• Bovine

• Mouse

• Vertebrates
  View All» Species Reactivity Note: Human, mouse, bovine. Broad species cross-reactivity is expected, based on sequence homology. View All» Application Notes: Immunohistochemistry: This antibody has been reported by an independent laboratory to detect CDK (cyclin dependent kinase) phosphorylated Histone H1 in benign tissue sections.1Immunocytochemistry: This antibody has been demonstrated by an outside laboratory to show positive immunostaining for phosphorylated histone H1 in HUSK (human fetal primary myoblasts) cells fixed with 3.7% paraformaldehyde followed by permeabilization with 0.2% Triton X-100.2Immunoprecipitation: This antibody has been demonstrated by an outside laboratory to immunoprecipitate phosphorylated histone H1 using solid phase beads bound to anti-mouse IgM. View All» Control: HeLa cell lysate, treated with colcemid. View All» Quality Assurance: Western Blot Analysis: 1:1000 dilution of this antibody detected Histone H1 in colcemid-treated HeLa lysate. View All» Presentation: Supplied as 200 μL of culture supernatant with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P16401 View All» Entrez Gene Number: NM_005319 View All» Gene Symbol:
  • H1

  • H1.5

  • H1F5

  • MGC126630

  • MGC126632

  • OTTHUMP00000017748
    View All» Alternate Names:
    • H1 histone family, member 5

    • Histone H1a

    • histone 1, H1b

    • histone cluster 1, H1b
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunocytochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the histone H1/H5 family. View All» Product Name: Anti-phospho-Histone H1, clone 12D11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 μL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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