货号：05-1328

品牌：Merck Millipore

规格：

目录价：￥4077.00

市场价格：￥3465.45

会员价格：￥3261.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PHD3 Antibody, clone 188e | 05-1328 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PHD3. View All» Molecular Weight: ~ 27 kDa View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human PHD3. View All» Clone: 188e View All» Isotype: IgG1κ View All» Background Information: PHD3 (Prolyl hydroxylase domain-containing protein 3), also known as Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3 or HPH-1), is one of 4 PHD (PHD1-4) proteins which function as prolyl hydroxylases to effect oxygen homeostasis via hypoxia-inducible factor (HIF). This transcriptional complex is composed of an alpha-beta heterodimer that mediates a broad range of cellular and systemic responses to hypoxia. The PHD proteins hydroxylate HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. PHD3, is expressed in response to hypoxia and causes apoptosis in oxygenated conditions in neural cells. When oxygen levels are normal, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha. This post-translational modification targets this protein for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human placenta tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human placenta tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PHD3 on 10 µg of human placenta tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9H6Z9 View All» Entrez Gene Number: NP_071356.1 View All» Gene Symbol:

• EGLN3

• HIF-PH3

• HIFPH3

• HPH-1

• PHD3
  View All» Alternate Names:
  • EGL nine (C.elegans) homolog 3

  • HIF prolyl hydroxylase 3

  • HIF-prolyl hydroxylase 3

  • Hypoxia-inducible factor prolyl hydroxylase 3

  • Prolyl hydroxylase domain-containing protein 3

  • egl nine homolog 3

  • egl nine homolog 3 (C. elegans)

  • egl nine-like protein 3 isoform
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism By similarity.CATALYTIC ACTIVITY: An HIF alpha chain L-proline + 2-oxoglutarate + O2 = An HIF alpha chain trans-4-hydroxy-L-proline + succinate + CO2. COFACTOR: Binds 1 Fe2+ ion per subunit.Ascorbate.ENZYME REGULATION: Activated in cardiovascular cells and HelA cells following exposure to hypoxia. SUBUNIT STRUCTURE: Interacts with MORG1 By similarity.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed at low levels. Expressed at higher levels in heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle) and placenta. SEQUENCE SIMILARITIES: Contains 1 PKHD (prolyl/lysyl hydroxylase) domain. View All» Product Name: Anti-PHD3, clone 188e View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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