货号：05-1425

品牌：Merck Millipore

规格：EA

目录价：￥3144.00

市场价格：￥2672.40

会员价格：￥2515.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-14-3-3 Antibody, 33 kDa isoforms, clone 8C3 | 05-1425 View All» Replaces: MAB3053 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Clone 8C3 is specific for the 33 kDa epsilon isoform of 14-3-3 proteins and does not cross react with the 30 kDa 14-3-3 isoforms View All» Molecular Weight: 33 kDa View All» Epitope: a.a. 208-244 View All» Immunogen: Directed against a synthetic peptide corresponding to rat 14-3-3 epsilon, amino acids 208-244. View All» Clone: 8C3 View All» Isotype: IgG2a View All» Background Information: Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's. View All» Species Reactivity:

• Rat

• Sheep

• Human
  View All» Species Reactivity Note: Reacts with human. Expected to react in rat and sheep. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysates.Western Blot Analysis: 1:500 dilution of this lot detected 14-3-3 PROTEINS on 10 ug of Jurkat lysates. View All» Purification Method: Unpurified, ascites liquid. View All» Presentation: Ascites. Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P62258 View All» Entrez Gene Number: P62258 View All» Gene Symbol:
  • YWHAE

  • KCIP-1

  • MDS

  • 14-3-3E

  • MDCR

  • FLJ45465
    View All» Alternate Names:
    • 14-3-3 epsilon

    • 14-3-3 protein epsilon

    • mitochondrial import stimulation factor L subunit

    • protein kinase C inhibitor protein-1

    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation

    • protein, epsilon polypeptide

    • tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P62258 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.SIZE: 255 amino acids; 29174 Da SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SIMILARITY: SwissProt: P62258 ## Belongs to the 14-3-3 family. View All» Product Name: Anti-14-3-3, 33 kDa isoforms, clone 8C3 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 μL View All» Format: Ascites View All» Host: Mouse View All»
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