货号：05-1426

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SLP-76 Antibody, clone AS55 | 05-1426 View All» Replaces: 05-1426 is a recommended replacement for MAB3756 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes human SH2 (Src homology 2) domain-Leukocyte Protein of 76 kDa. View All» Molecular Weight: Detects SLP-76 (SH2 domain containing Leukocyte Protein) of 76 kDa View All» Immunogen: Monoclonal antibody from BALB/c-derived hybridoma View All» Clone: AS55 View All» Isotype: IgG2a View All» Background Information: Detects SLP-76 (SH2 domain containing Leukocyte Protein) of 76 kDa, a hematopoietic cell-specific adapter protein which intereacts with other signaling molecules through amino-terminal phosphotyrosine residues, a central proline-rich region and a carboxyl-terminal Src homology 2 domain (SH2). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and mouse. Expected to react with rat based on sequence homology. View All» Application Notes: Immunoprecipitation: A previous lot of this antibody was used in IP.Optimal working dilutions must be determined by end user. View All» Control: RAW264 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on RAW 264 lysates.Western Blot Analysis: 1:500 dilution of this lot detected SLP-76 on 10 μg of RAW 264 lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2a 0.2 mm sterile filtered solution in phosphate buffered saline with 0.1% sodium azide. View All» Storage Conditions: Stable at -20°C in undiluted aliquots for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q13094 View All» Entrez Gene Number: NM_005565.3 View All» Gene Symbol:
  • LCP2

  • SLP-76

  • SLP76
    View All» Alternate Names:
    • 76 kDa tyrosine phosphoprotein 2

    • Human 76 kDa tyrosine phosphoprotein SLP-76 mRNA, complete cds

    • Lymphocyte cytosolic protein 2

    • SH2 domain-containing leukocyte protein of 76 kDa

    • SLP-76 tyrosine phosphoprotein

    • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function View All» UniProt Summary: FUNCTION: SwissProt: Q13094 # Involved in T-cell antigen receptor mediated signaling.SIZE: 533 amino acids; 60188 Da SUBUNIT: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Highly expressed in spleen, thymus, and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblasatoma cell lines.DOMAIN:SwissProt: Q13094 The SH2 domain mediates interaction with SHB.PTM: Phosphorylated after T-cell receptor activation by ZAP-70.SIMILARITY: Contains 1 SH2 domain. View All» Product Name: Anti-SLP-76 Antibody, clone AS55 | 05-1426 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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