货号：05-1427

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ARF1 Antibody, clone 3F1 | 05-1427 View All» Replaces: 05-1427 is a recommended replacement for MAB3779 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes human ARF1 View All» Molecular Weight: ~21 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to the C-terminal amino acid sequence of human ARF1. View All» Clone: 3F1 View All» Isotype: IgG2a View All» Background Information: ARF1 is a member of the ARF family of small G proteins and is a component of Golgi-derived non-clathrin coated vesicles. This antibody is class 1 ARF specific. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse and rat. View All» Application Notes: ELISA: A previous lot of this antibody was used in ELISA.Optimal working dilutions must be determined by end user.Immunohistochemistry(paraffin): Representative testing from a previous lot.Optimal Staining of ARF1 Monoclonal Antibody: Skin & Breast Cancer View All» Control: HeLa cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HeLa lysates.Western Blot Analysis: 1:500 dilution of this lot detected ARF1 on 10 μg of HeLa lysates. View All» Purification Method: Purified View All» Presentation: Purified mouse monoclonal IgG2a in 0.02 M phosphate buffer, 0.25 M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Stable at 2-8°C in undiluted aliquots for up to 1 year from date of receipt. View All» UniProt Number: P84077 View All» Entrez Gene Number: NM_001024226.1 View All» Gene Symbol: ARF1 View All» Alternate Names: ADP-ribosylation factor 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • ELISA

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P84077 # GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.SIZE: 181 amino acids; 20697 Da SUBUNIT: Interacts with PRKCABP, GGA1, DDEF2 and PIP5K1A (By similarity). Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Binds DDEF2. Interacts with ARHGAP21.SIMILARITY: SwissProt: P84077 ## Belongs to the small GTPase superfamily. Arf family View All» Product Name: Anti-ARF1 Antibody, clone 3F1 | 05-1427 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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