货号：05-1482

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GβL/mLST8 Antibody, clone 3E1.2 | 05-1482 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GβL/mLST8. View All» Molecular Weight: 36 kDa View All» Immunogen: GST-tagged recombinant human GβL/mLST8. View All» Clone: 3E1.2 View All» Isotype: IgG1κ View All» Background Information: GβL (G protein beta protein subunit-like), also known as mLST8, is a member of the mammalian Target of Rapamycin (mTOR) complex. The complex composed of mTOR, regulatory associated protein of mTOR (Raptor) and mammalian LST8/G-protein β-subunit like protein (mLST8/GβL) is responsible for regulating cell growth and nutrient and growth factor-mediated mTOR signaling. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Proven to react with human and mouse. View All» Application Notes: Immunocytochemistry Analysis: View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GβL/mLST8 in HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse ascites in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for 1 year from date of receipt. View All» UniProt Number: Q9BVC4 View All» Entrez Gene Number: NP_071767.3 View All» Gene Symbol:
  • Gable

  • LST8

  • MGC111011

  • OTTHUMP00000159046

  • POP3

  • WAT1

  • mLST8
    View All» Alternate Names:
    • G protein beta subunit-like

    • Protein GbetaL

    • TORC subunit LST8

    • Target of rapamycin complex subunit LST8
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Unessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals, and is inactivated by nutrient limitation and environmental stress. Within TORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient-poor conditions, stabilizes the FRAP1-RAPTOR interaction and favors RAPTOR-mediated inhibition of FRAP1 activity. TORC2 controls polarity of the actin cytoskeleton via the RAC1 pathway. TORC2 mediates phosphorylation of Akt/PKB on 'Ser-473' and phosphorylation of PKCalpha on 'Ser-657'. SUBUNIT STRUCTURE: Interacts with FRAP1, RAPTOR and RHEB. Part of the target of rapamycin complex 1 (TORC1) which contains LST8, FRAP1, RAPTOR and AKT1S1. TORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the target of rapamycin complex 2 (TORC2) which contains FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. SUBCELLULAR LOCATION: Cytoplasm By similarity. TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle, heart and kidney. Ref.6SEQUENCE SIMILARITIES: Belongs to the WD repeat LST8 family.Contains 7 WD repeats. View All» Product Name: Anti-GβL/mLST8, clone 3E1.2 View All» Concentration: 3E1.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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