货号：05-1512

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FMR1 Antibody, clone 6A15 | 05-1512 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FMR1. View All» Molecular Weight: 85 kDa was observed; however, additional bands were observed at 50, 55, and 80 kDa. View All» Epitope: Unknown View All» Immunogen: His-tagged recombinant protein corresponding to Drosophila FMR1. View All» Clone: 6A15 View All» Isotype: IgG1κ View All» Background Information: Fragile X Mental Retardation 1 (FMR1) is a RNA-binding protein that is associated to polysomes and may be involved in the transport of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region. View All» Species Reactivity: Drosophila View All» Species Reactivity Note: Demonstrated to react with Drosophila. View All» Control: Drosophila Schneider L2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Drosophila Schneider L2 cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected FMR1 on 10 µg of Drosophila Schneider L2 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q9NFU0 View All» Entrez Gene Number: NP_611645.1 View All» Gene Symbol:

• FMR1

• FMRP

• FRAXA

• POF

• POF1
  View All» Alternate Names:
  • Protein FMR-1

  • fragile X mental retardation 1

  • premature ovarian failure 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator of specific mRNAs. Represses translation of futsch to regulate microtubule-dependent synaptic growth and function. Part of the RNA interference (RNAi)-related apparatus; double-stranded RNA induces potent and specific gene silencing. Regulates photoreceptor structure and neurotransmission in the eye. Required for stability of the central pair of microtubules in the spermatid axoneme. SUBUNIT STRUCTURE: Homodimer. Interacts with futsch and Sra-1. Interacts with the ribosome to form a ribonucleoprotein (RNP) complex, involved in translation regulation, with mRpL5 and mRpL11 on the ribosomal surface. The complex also contains AGO2, Dcr-1 and Rm62. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Until early gastrulation, expression is uniformly distributed in the embryo. At mid-gastrulation (stage 11), expression everywhere with discernible concentration in the mesoderm. After gastrulation (stage 14), expression is significantly elevated in the mesoderm, ventral nerve cord, and brain. At stage 16, elevated expression is also seen in the muscle. Highly expressed in nervous system throughout later development. Highly expressed in testes in the early stages of spermatogenesis before spermatid individualization. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically in embryos. SEQUENCE SIMILARITIES: Belongs to the FMR1 family.Contains 2 KH domains. View All» Product Name: Anti-FMR1, clone 6A15 Antibody (05-1512) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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