货号：05-1513

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FXR2 Antibody, clone A42 | 05-1513 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FXR2. View All» Molecular Weight: 90 kDa. Possible dimer (~180 kDa) may be observed at lower dilutions or antibody. View All» Epitope: Unknown View All» Immunogen: His-tagged recombinant protein corresponding to human FXR2. View All» Clone: A42 View All» Isotype: IgG1κ View All» Background Information: Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. FXR2 is very similar to FMR1 (60% identity). FXR2 encodes a 74 kDa protein which, like FMR1, contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The FXR2 gene is located on human chromosome 17 at 17p13.1. In addition, FMR1 and FXR2 interact tightly with the recently described autosomal homolog FXR1. Each of these three proteins is capable of forming heterodimers with the others, and each can also form homodimers. FXR1 and FXR2 are thus likely to play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Application Notes: Immunoprecipitation: Siomi, M.C., et al. (1996). Mol Cell Biol. 16(7):3825-3832Immunocytochemistry: Wan, L., et al. (2000). Mol Cel Biol. 20(22) 8536-8547 View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in jurkat cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected FXR2 on 10 µg of jurkat cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51116 View All» Entrez Gene Number: NP_004851.2 View All» Gene Symbol:

• FXR2

• FMR1L2
  View All» Alternate Names:
  • fragile X mental retardation syndrome related protein 2

  • fragile X mental retardation, autosomal homolog 2

  • fragile X-mental retardation 1-like 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. View All» UniProt Summary: FUNCTION: RNA-binding protein.SUBUNIT STURCUTRE: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. SUBCELLULAR LOCATION: Cytoplasm. SEQUENCE SIMILARITIES: Belongs to the FMR1 family. View All» Product Name: Anti-FXR2, clone A42 Antibody (05-1513) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-132587.htm
      © Merck Millipore代理05-1513 Anti-FXR2, clone A42 (mouse monoclonal)，产品报价联系微信jinshanbio