货号：05-1515

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Transportin 1 Antibody, clone D45 | 05-1515 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Transportin-1. View All» Molecular Weight: ~ 102 kDa View All» Epitope: Unknown View All» Immunogen: Histidine-tagged recombinant protein corresponding to human Transportin-1. View All» Clone: D45 View All» Isotype: IgG1κ View All» Background Information: Transportin 1 (Trn1) is a transport receptor that transports substrates from the cytoplasm to the nucleus through nuclear pore complexes by recognizing nuclear localization signals (NLSs). Transportin 1 is a mediator of hnRNP A1 transport into the nucleus. Trn1 has two sites for binding NLSs, one with high affinity and second with low affinity. Interactions at the low affinity site controls overall binding affinity. Trn1 recognizes NLSs at the high affinity site followed by a conformational change at the low affinity site that interacts with NLSs. Alternate splicing of the Trn1 gene results in two transcript variants encoding different proteins. View All» Species Reactivity:

• Human

• Monkey

• Rabbit
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with monkey and rabbit based on 100% sequence homology. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected Transportin-1 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q92973 View All» Entrez Gene Number: NP_002261.3 View All» Gene Symbol:
  • TNPO1

  • TRN

  • IPO2

  • KPNB2

  • MIP

  • MIP1
    View All» Alternate Names:
    • Importin beta-2

    • Karyopherin beta-2

    • M9 region interaction protein

    • importin 2

    • importin beta 2

    • karyopherin (importin) beta 2

    • transportin 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.SUBUNIT STRUCTURE: Binds HNRPA1, HNRPA2, HNRPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SEQUENCE SIMILARITIES: Belongs to the importin beta family.Contains 8 HEAT repeats.Contains 1 importin N-terminal domain. View All» Product Name: Anti-Transportin 1, clone D45 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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