货号：05-1527

品牌：Merck Millipore

规格：100Ug

目录价：￥4611.00

市场价格：￥3919.35

会员价格：￥3688.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-eIF4A3 Antibody, clone 3F1 | 05-1527 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes eIF4A3. View All» Molecular Weight: 47 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human eIF4A3. View All» Clone: 3 F 1 View All» Isotype: IgG1κ View All» Background Information: Eukaryotic translation initiation factor 4A, isoform 3, also known as eIF4A3, is a member of the DEAD box protein family. DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). This family of proteins are putative RNA helicases and are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. eIF4A3 is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with mouse based on sequence homology. View All» Application Notes: Immunoprecipitation: Reported by independent laboratory using representative lot.Immunocytochemistry: Reported by independent laboratory using representative lot. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected eIF4A3 on 10 µg in HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P38919 View All» Entrez Gene Number: NP_055555.1 View All» Gene Symbol:
  • DDX48

  • EIF4AIII

  • NMP265

  • NUK-34

  • eIF4AIII

  • hNMP265
    View All» Alternate Names:
    • ATP-dependent RNA helicase DDX48

    • ATP-dependent RNA helicase eIF4A-3

    • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48

    • DEAD box protein 48

    • Eukaryotic initiation factor 4A-like NUK-34

    • Eukaryotic translation initiation factor 4A isoform 3

    • Nuclear matrix protein 265

    • eukaryotic translation initiation factor 4A, isoform 3

    • hNMP 265
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq]. View All» UniProt Summary: FUCTION: Binds to spliced mRNAs and is involved in nonsense-mediated decay of mRNAs containing premature stop codons.SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, EIF4A3, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Part of the exon junction complex (EJC), a multisubunit complex which assembles near mRNA exon-exon junctions and which contains proteins involved in mRNA splicing, export, localization and nonsense-mediated decay. May interact with NOM1.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. SEQUENCE SIMILARITIES: Belongs to the DEAD box helicase family. eIF4A subfamily.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain. ... View All» Product Name: Anti-eIF4A3, clone 3F1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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