货号：05-1558

品牌：Merck Millipore

规格：

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PI3 Kinase b Antibody, p110b, clone 8C3.2 | 05-1558 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PI3 Kinase b at the N-terminus. View All» Molecular Weight: ~110 kDa observed View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human PI3 Kinase b. View All» Clone: 8C3.2 View All» Isotype: IgMκ View All» Background Information: PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. View All» Species Reactivity:

• Rat

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution positively stained NIH3T3 cell lysate. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC-12 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected PI3 Kinase b on 10 µg of PC-12 cell lysate. View All» Purification Method: Ion Exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P42338 View All» Entrez Gene Number: NP_006210 View All» Gene Symbol:
  • PIK3CB

  • PI3Kbeta

  • PIK3C1
    View All» Alternate Names:
    • PI3-kinase p110 subunit beta

    • PtdIns-3-kinase p110

    • phosphatidylinositol 3-kinase, catalytic, beta polypeptide

    • phosphoinositide-3-kinase, catalytic, beta polypeptide

    • PI3K beta

    • PI3 K beta

    • PI3 kinase b
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.SUBUNIT STRUCTURE: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.TISSUE SPECIFICITY: Expressed ubiquitously.SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.Contains 1 PI3K/PI4K domain. View All» Product Name: Anti-PI3 Kinase b, p110b, clone 8C3.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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