货号：05-1567

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p120 Catenin Antibody, clone 15D2 | 05-1567 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes p120 Catenin View All» Molecular Weight: 90-120 kDa View All» Epitope: C-terminus View All» Immunogen: Recombinant fusion protein derived from the C-terminus of murine p120 View All» Clone: clone 15D2 View All» Isotype: IgG1κ View All» Background Information: p120 Catenin is a cadherin-associated protein that binds intracellular proteins, such as the small GTPase, RhoA, and controls E-cadherin funcation and stability. Proteins of the p120 family and their isoforms are expressed in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and Mouse. Predicted to react with Rat based on homology. View All» Application Notes: Immunocytochemistry: View All» Control: Hela cell lysate. View All» Quality Assurance: Evaluated by Western Blot on Hela cell lysate.Western Blot Analysis: 1 g/mL of this antibody detected p120 Catenin in lysate from Hela cells. View All» Purification Method: Protein G chromatography View All» Presentation: Purified mouse monoclonal in 0.1M Tris-Glycine (pH 7.4), 150mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: O60716 View All» Entrez Gene Number: O60716 View All» Gene Symbol:
  • CAS

  • CTNND

  • KIAA0384

  • P120CAS

  • p120

  • P120CTN

  • p120(cas)

  • p120(ctn)

  • p120cas

  • p120ctn
    View All» Alternate Names:
    • Cadherin-associated Src substrate

    • catenin (cadherin-associated protein), delta 1

    • catenin, delta 1

    • p120 catenin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Flow Cytometry
        View All» UniProt Summary: FUNCTION: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.SUBUNIT STRUCTURE: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membraneBy similarity. Note= Interaction with GLIS2 promotes nuclear translocation By similarity.TISSUE SPECIFICITY: Expressed in vascular endothelium. INDUCTION: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. DOMAIN: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.PTM: Phosphorylated By similarity.INVOLVEMENT IN DISEASE: May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.SEQUENCE SIMILARITIES: Belongs to the beta-catenin family.Contains 10 ARM repeats. View All» Product Name: Anti-p120 Catenin, clone 15D2 View All» Concentration: clone 15D2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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