货号：MAB88060

品牌：Merck Millipore

规格：

目录价：￥2796.00

市场价格：￥2376.60

会员价格：￥2236.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p95 vav, clone VAV-30 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB88060 recognizes a 95 kDa protein which is identified as the p95vav. VAV-30 MAB is highly specific to p95vav, a proto-oncogene expressed in hematopoietic cells. p95vav contains a series of structural motifs found in intracellular signaling molecules and is tyrosine phosphorylated upon activation of hematopoietic cells through their surface receptors, such as the B cell IgM receptor complex or the T cell receptor-CD4 complex. it is also phosphorylated on serine and threonine. p95vav contains SQ and one TQ sequences. Using the yeast two-hybrid system, it was shown that p70 Ku interacts with aa 813-837 of p95vav, part of the carboxyl-terminal Src homology 3 (SH3) domain. The interaction does not involve binding of the SH3 domain to a proline-rich domain of Ku. Instead, p95vav binds to aa 463-609 of p70 Ku, a region containing the DNA binding domain as well as leucine zipper-like motif. The leucine zipper (aa483-498) is not sufficient for the interaction with p95vav. View All» Immunogen: Purified human recombinant full length p95vav-GST fusion protein View All» Clone: VAV-30 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunoprecipitation: 10 μL/mg protein lysate. Western Blot: 1:200-1:400 Immunofluorescence (cytoplasmic) Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Jurkat cells View All» Presentation: Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4 with 0.2% BSA and 15 mM sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: P15498 View All» Entrez Gene Number: NM_005428 View All» Gene Symbol:
  • NBN

  • P95

  • MGC87362

  • FLJ10155

  • ATV

  • NBS

  • AT-V1

  • Nibrin

  • AT-V2

  • NBS1
    View All» Alternate Names: Proto-oncogene vav View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq] View All» UniProt Summary: Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.Subunit structure: May interact with CCPG1 By similarity. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK By similarity.Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types.Domain: The DH domain is involved in interaction with CCPG1 By similarity.Post-translational modification: Phosphorylated on tyrosine residues. Sequence similarities Contains 1 CH (calponin-homology) domain.Contains 1 DH (DBL-homology) domain.Contains 1 PH domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 SH2 domain.Contains 2 SH3 domains. View All» Brand Family: Chemicon View All» Product Name: Anti-p95 vav, clone VAV-30 View All» Concentration: 0.2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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