货号：MAB88079

品牌：Merck Millipore

规格：50Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Heat Shock Factor II Antibody, clone 3E2 | MAB88079 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB88079 recognizes a protein of 70 kDa, identified as Heat Shock Factor 2 (HSF2). The synthesis of heat shock proteins is dependent on transcriptional and post-transcriptional control in eukaryotic cells. The regulation of heat shock gene transcription is mediated by the transcriptional activator, Heat Shock Factor (HSF), which binds to heat shock response elements (HSEs). At least three HSFs have been isolated from the human, mouse, chicken, and tomato genomes and an additional factor, HSF4 has been identified in humans. HSFs purified from yeast, Drosphila, and human have different molecular weights and do not cross-react immunologically. These factors are activated by distinct stimuli. HSF1 responds to cellular stress signals such as heat, heavy metals, and oxidative reagents whereas, the HSF2 is activated during differentiation. some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA. the phosphorylation of HSF1 may be necessary for maximal transcription of heat shock genes. View All» Immunogen: Full length recombinant mouse HSF2 proteins (aa 1-517) View All» Clone: 3E2 View All» Isotype: IgG2a View All» Species Reactivity:

• Human

• Mouse

• Monkey
  View All» Application Notes: Immunofluorescence Immunohistology (predominantly cytoplasmic with some nuclear). Immunoprecipitation: 2 μg/mg protein lysate. Western blot. 1:200-1:400 ELISA Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: NIH-3T3 cells View All» Presentation: Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4, with 0.2% BSA and 15 mM sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q03933 View All» Entrez Gene Number: NM_004506.2 View All» Gene Symbol:
  • HSF2

  • MGC117376

  • MGC75048

  • HSTF2

  • MGC156196
    View All» Alternate Names: HSFII View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors. View All» UniProt Summary: FUNCTION: SwissProt: Q03933 # DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.SIZE: 536 amino acids; 60348 Da SUBUNIT: DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.SIMILARITY: SwissProt: Q03933 ## Belongs to the HSF family. View All» Brand Family: Chemicon View All» Product Name: Anti-Heat Shock Factor II Antibody, clone 3E2 | MAB88079 View All» Concentration: 100 mg/0.5 mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rat View All»
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