货号：MAB8864

品牌：Merck Millipore

规格：50Ug

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-myc Antibody, a.a. 410-419, clone 9E10.3 | MAB8864 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB8864 recognizes an oncoprotein of 64-67 kDa, identified as c-myc. Its eptiope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. MAB8864 shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. View All» Epitope: a.a. 410-419 View All» Immunogen: A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc, coupled to KLH. View All» Clone: 9E10.3 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Non-Reactive Species:

• Chicken

• Mouse

• Rat
  View All» Application Notes: Flow Cytometry Western Blot: 1:200-1:400 Electron Microscopy Immunofluorescence (Predominantly nuclear with some cytoplasmic) Immunohistology (frozen & formalin/paraffin): 1:50-1:100 (30-60 mins. at RT) Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: HL-60 cells. Breast tumors. View All» Presentation: Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months. View All» UniProt Number: P01106 View All» Entrez Gene Number: NM_002467.3 View All» Gene Symbol:
  • MYC

  • C-MYC

  • c-Myc
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated by PRKDC.DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-c-myc Antibody, a.a. 410-419, clone 9E10.3 | MAB8864 View All» Concentration: 100 μg/500 μL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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