货号：MAB8879

品牌：Merck Millipore

规格：50Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cdk4 Antibody, clone DCS-35 | MAB8879 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a 34 kDa protein identified as p34 or cyclin-dependent kinase 4 (cdk4). It shows no cross-reaction with other cdks. View All» Immunogen: Raised against purified recombinant cdk4 protein. View All» Clone: DCS-35 View All» Isotype: IgG1κ View All» Background Information: The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. View All» Species Reactivity:

• Human

• Mouse

• Pig

• Rat
  View All» Application Notes: Immunofluorescence Immunoprecipitation: excellent for coprecipitation of D-type cyclins bound to cdk4. Western Blotting: 2-4 ug/mL Kinase Assay The prototype of the cdk family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4 with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain liquid material at 2-8°C for up to 24 months. View All» UniProt Number: P11802 View All» Entrez Gene Number: NM_000075.2 View All» Gene Symbol:
  • CDK4

  • PSK-J3

  • CMM3

  • MGC14458

  • EC 2.7.11.22
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Enzyme Assay

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P11802 # Probably involved in the control of the cell cycle.SIZE: 303 amino acids; 33730 Da SUBUNIT: Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK.DISEASE: SwissProt: P11802 # CDK4 mutations are involved in tumor formation. & Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048, 155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a preexisting benign nevus, which occurs most often in the skin but also may involve other sites.SIMILARITY: SwissProt: P11802 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Cdk4 Antibody, clone DCS-35 | MAB8879 View All» Concentration: 200 ug/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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