货号：MAB8900

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fyn Antibody, clone 1S | MAB8900 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB8900 recognizes a protein of 59 kDa which is identified as Fyn. P59fyn is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. MAB8900 shows no cross-reaction with other members of the Src protein kinase family. Its epitope spans between aa 26-75 of the unique region of p59fyn. The unique N-terminal domain of p59fyn interacts with the CD3 and zeta chains of the TcR. p59fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. p59fyn is highly expressed in brain suggesting that It may have a role in the sensory nervous network and in myelination at early stages of CNS formation. View All» Immunogen: Recombinant protein construct corresponding to aa 1-206 of murine p59fyn protein. View All» Clone: 1S View All» Isotype: IgG1κ View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot Kinase Assay Immunohistology: For frozen and formalin/paraffin, 1-2 μg/mL for 30 minutes at room temperature. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at room temperature for 20 min. View All» Control: POSITIVE CONTROL: Jurkat cells, lymphoma. View All» Presentation: Immunoglobulin purified by Protein G chromatography. Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P06241 View All» Entrez Gene Number:
  • NM_002037.3

  • NM_153047.1

  • NM_153048.1
    View All» Gene Symbol:
    • FYN

    • MGC45350

    • SYN

    • SLK

    • p59-Fyn

    • EC 2.7.10.2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Enzyme Assay

      • Western Blotting
        View All» Entrez Gene Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. View All» UniProt Summary: FUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.COFACTOR: Manganese.SIZE: 537 amino acids; 60762 Da SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Fyn Antibody, clone 1S | MAB8900 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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