货号：MABC187

品牌：Merck Millipore

规格：

目录价：￥4755.00

市场价格：￥4041.75

会员价格：￥3804.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1 | MABC187 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody only detects the R132S mutation of Isocitrate Dehydrogenase (IDH1). View All» Molecular Weight: ~50 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1)-R132S. View All» Clone: Smab-1 View All» Isotype: IgG1κ View All» Background Information: Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Western Blot Analysis: A 1:250 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in a panel of CHO cell lysates expressing wild-type and mutated IDH1.Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in gliblastoma tissues that express the IDH1-R132S mutation.Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in IDH1-R132S-transfected LN229 cells. View All» Control: S8 overexpressing CHO cell lysate View All» Quality Assurance: Evaluated by Western Blot in S8 overexpressing CHO cell lysate.Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in S8 overexpressing CHO cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75874 View All» Entrez Gene Number: NP_005887 View All» Gene Symbol:

• IDH1

• PICD
  View All» Alternate Names:
  • Isocitrate dehydrogenase [NADP] cytoplasmic

  • IDH

  • Cytosolic NADP-isocitrate dehydrogenase

  • IDP

  • NADP(+)-specific ICDH

  • Oxalosuccinate decarboxylase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Product Name: Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S, clone SMab-1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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