货号：MABC205

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cyclin A2 Antibody, clone 17B8.2 | MABC205 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~60 kDa observed. A mature form of this protein is observed at ~60 kDa. A truncated form may also observed at 40-55 kDa in some cell lysates. (Anger, M. et al. (1994). Biochem Biophys Res Commun. 302(4):825-830. Yam, C.H., et al. (2001). Proc Natl Acad Sci USA. 98(2):497-501.) View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human Cyclin A2. View All» Clone: 17B8.2 View All» Isotype: IgMκ View All» Background Information: The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. As a member of the Cyclin A family, Cyclin A2 associates with both Cdk1 and Cdk2 to form a serine/threonine kinase holoenzyme complex. Cyclin A2 also phosphorylates substrates similar to those of cyclin E-Cdk and regulates the cell cycle at G1/S and the G2/M phase. View All» Species Reactivity:

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. View All» Application Notes: Flow Cytometry Analysis: 0.5 µg from a representative lot detected Cyclin A2 in HeLa cells. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC-12 cell lysate.Western Blot Analysis: A 1:50,000 dilution of this antibody detected Cyclin A2 in 10 µg of PC-12 cell lysate. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P20248 View All» Entrez Gene Number: NP_001228 View All» Gene Symbol:
  • CCNA2

  • CCN1

  • CCNA
    View All» Alternate Names:
    • Cyclin-A2

    • Cyclin-A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» Entrez Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. View All» UniProt Summary: FUNCTION: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.SUBUNIT STRUCTURE: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Cytoplasmic when associated with SCAPER. View All» Product Name: Anti-Cyclin A2, clone 17B8.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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