货号：MABC28

品牌：Merck Millipore

规格：200UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RIP3 Antibody, clone 6E6.2 | MABC28 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RIP3 at the N-terminus. View All» Molecular Weight: ~56 kDa (isoform 1) and ~27 kDa (isoform 2) observed. Isoform 3 (~25 kDa) may be observed in some lysates. An uncharacterized band may be observed at ~16 kDa in some lysates. View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to human RIP3 at the N-terminus. View All» Clone: 6E6.2 View All» Isotype: IgG2aκ View All» Background Information: Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and rat. View All» Application Notes: Western Blot Analysis: A 1:1,000 dilution from a representative lot detected RIP3 in 10 µg of human placenta tissue lysate.Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected RIP3 in rat pancreas tissue. View All» Control: Human pancreas tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human pancreas tissue lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected RIP3 in 10 µg of human pancreas tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y572 View All» Entrez Gene Number: NP_006862 View All» Gene Symbol:
  • RIPK3

  • RIP3
    View All» Alternate Names:
    • Receptor-interacting serine/threonine-protein kinase 3

    • RIP-like protein kinase 3

    • Receptor-interacting protein 3

    • RIP-3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Promotes apoptosis.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBUNIT STRUCTURE: Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.SUBCELLULAR LOCATION: Cytoplasm Probable. TISSUE SPECIFICTY: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. PTM: Autophosphorylated (By similarity).SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 1 protein kinase domain. View All» Product Name: Anti-RIP3, clone 6E6.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
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