货号：MABC36

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dog1 Antibody, clone 1.1 | MABC36 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 114 kDa calculated View All» Immunogen: Linear peptide corresponding to human Dog1. View All» Clone: 1.1 View All» Isotype: IgG1κ View All» Background Information: Discovered on gastrointestinal stromal tumors protein 1 (Dog1), also known as Anoctamin-1, is a novel multi-pass membrane protein belonging to the anoctamin family. Dog1 functions as a Ca2+-activated Cl- channel and is a required component of tracheal development. Expression of Dog1 is elevated in the gastrointestinal stromal tumors (GISTs), KIT signaling-driven mesenchymal tumors of the GI tract. It is also expressed at more moderate levels in epithelia from foregut, kidney, lung, pancreas and salivary glands. Recent studies suggest that it may serve a roll as a diagnostic marker in the classification of GISTs. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Gastrointestinal cancer tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in gastrointestinal cancer tissue.Immunohistochemistry Analysis: 1:100 dilution of the antibody detected Dog1 in gastrointestinal cancer tissue. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q5XXA6 View All» Entrez Gene Number: NP_060513 View All» Gene Symbol:

• DOG1

• TAOS2

• ORAOV2

• ANO1
  View All» Alternate Names:
  • Anoctamin 1, calcium activated chloride channel

  • Discovered on gastrointestinal stromal tumors protein 1

  • Tumor-amplified and overexpressed sequence 2

  • Oral cancer overexpressed protein 2

  • Transmembrane protein 16A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: Acts as a calcium-activated chloride channel. Required for normal tracheal development (by similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm TISSUE SPECIFICTY: Broadly expressed with higher levels in liver and skeletal muscle. DOMAIN: The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region (by similarity).SEQUENCE SIMILARITIES: Belongs to the anoctamin family. View All» Product Name: Anti-Dog1, clone 1.1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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