货号：MABC74

品牌：Merck Millipore

规格：

目录价：￥4113.00

市场价格：￥3496.05

会员价格：￥3290.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BNIPL-2 Antibody, clone 8C11.1 | MABC74 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~40 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human BNIPL-2. View All» Clone: 8C11.1 View All» Isotype: IgG1κ View All» Background Information: Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like (BNIPL-2; BNIPL) is a ubiquitous protein which has over 70 % homology to the BNIP-2 protein. BNIPL-2 induces apoptosis by interaction with Bcl-2 and Cdc42GAP proteins via its BCH domain. Through this association, BNIPL-2 promotes disruption of cell membranes and DNA fragmentation processes in cells undergoing stress such as viral invasion. Previous studies have indicated that BNIPL-2 may contribute to metastastic processes in cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react in Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BNIPL-2 in human breast ductal carcinoma tissue. View All» Control: Y79 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Y79 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected BNIPL-2 on 10 µg of Y79 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q7Z465 View All» Entrez Gene Number: NP_001153114 View All» Gene Symbol:

• BNIPL

• BNIPL-2
  View All» Alternate Names: Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. View All» UniProt Summary: FUNCTION: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. SUBUNIT STRUCTURE: Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER. TISSUE SPECIFICITY: Isoform 2 is expressed in placenta and lung. SEQUENCE SIMILARITIES: Contains 1 CRAL-TRIO domain. View All» Product Name: Anti-BNIPL-2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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