货号：MABD20

品牌：Merck Millipore

规格：100Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PAX7 Antibody, clone 2F12H4 | MABD20 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 55 kDa observed.The calculated MW of PAX7 is 55 kDa; however, expression of PAX7 can have multiple isoforms. (Robert B., et al. (2008). Physiol. Genomics 33:41-49.) View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse PAX7. View All» Clone: 2F12H4 View All» Isotype: IgG2bκ View All» Background Information: Paired box protein Pax-7 (PAX7) belongs to the Pax family of transcription factors, a highly conserved group of proteins with crucial roles in tissue homeostasis and organogenesis. PAX7 is involved in the specification, survival, maintenance, and self-renewal of skeletal muscle progenitors and myogenic progenitors. It is primarily expressed in newly activated and quiescent satellite cells. Studies have shown that on activation, quiescent satellite cells co-express MyoD with PAX7 prior to proliferation, after which one or the other transcription factor is downregulated. Downregulation of MyoD instead of PAX7 leads to withdrawal from the cell cycle and myogenic differentiation, causing the cell to return to seemingly quiescent state. Chromosomal aberrations relating to PAX7 have been linked to rhabdomysarcoma 2 (RMS2). View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse. Shown to react with human by an independent laboratory (Harada, A., et al. (2009). Hybridoma, 26:6. Hyb.2009.0039). View All» Application Notes: Immunocytochemistry: A previous lot of this antibody was shown to detect Pax7 localized in euchromatin of human Ewing’ssarcoma cells. The antibodies are detected with Alexa Fluor® 488-conjugated anti-rat IgG. Each sample is counterstained with hoechst (Harada, A., et al. (2009). Hybridoma, 26:6. Hyb.2009.0039). View All» Control: Mouse fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse fetal brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PAX7 in 10 µg of mouse fetal brain tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P47239 View All» Entrez Gene Number: NP_035169 View All» Gene Symbol:
  • PAX7

  • HUP1

  • RMS2

  • PAX7B

  • Hup1

  • HuP1
    View All» Alternate Names:
    • paired box 7

    • PAX7 transcriptional factor

    • paired box gene 7

    • paired box homeotic gene 7

    • paired box protein Pax-7

    • paired domain gene 7
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Probable transcription factor. May have a role in myogenesis.SUBUNIT STRUCTURE: Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity).SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed specifically during the development of the nervous and muscular system.SEQUENCE SIMILARITIES: Belongs to the paired homeobox family.Contains 1 homeobox DNA-binding domain.Contains 1 paired domain. View All» Product Name: Anti-PAX7, clone 2F12H4 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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