货号：MABE133

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CHD5 Antibody, clone 5A10 | MABE133 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~223 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse CHD5. View All» Isotype: IgG2aκ View All» Background Information: Chromodomain helicase DNA-binding protein 5 (CHD5) is a novel ATP-dependent chromatin remodeling factor. In normal cells CHD5 plays a role in apoptosis, cell proliferation, and aging, through modulation of the p19(Arf)/p53 pathway. However, CHD5 is downregulated in various cancer cell lines, possibly due to hypermethylation of the CHD5 promoter and miRNA-211 activity, indicating that it may also play a critical role as a tumor suppressor. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse based upon immunogen design. View All» Application Notes: Immunocytochemistry Analysis: A representative lot from an independent laboratory detected CHD5 in HeLa and L929 cells (Yoshimura, S., et al. (2010). Hybridoma. 29(1):636-66).Immunocytochemistry Analysis: A representative lot detected CHD5 in HeLa cells.Immunohistochemistry Analysis: A representative lot from an independent laboratory detected CHD5 in E12.5 mouse gut tissue. (Yoshimura, S., et al. (2010). Hybridoma. 29(1):636-66).Immunohistochemistry Analysis: A representative lot detected CHD5 in E12.5 mouse brain tissue.Western Blot Analysis: A representative lot detected CHD5 in L929, HeLa, Cos1, Y1, MCF7, and C2C12 cells, and in E12.5 mouse tissue lysate. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 mg/mL of this antibody detected CHD5 in 10 mg of HeLa cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q4QQN1 View All» Gene Symbol: Chd5 View All» Alternate Names:

• Chd5 protein

• Chromodomain helicase DNA-binding protein 5
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Product Name: Anti-CHD5, clone 5A10 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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