货号：MABE145

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Runx3 Antibody, clone R3-5G4 | MABE145 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~44 kDa observed View All» Epitope: 0 View All» Immunogen: Recombinant protein corresponding to human Runx3. View All» Clone: R3-5G4 View All» Isotype: IgG1κ View All» Background Information: Runx3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Runx3 in HCT116, SW620, and SW480 nuclear extracts. (Ito, K., et al. (2008). Cancer Cell. 14(3):226-237.) View All» Control: Daudi cell lysate. View All» Quality Assurance: Evaluated by Western Blot in Daudi cell lysate.Western Blot Analysis: 0.25 mg/mL of this antibody detected Runx3 in 10 µg Daudi cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13761 View All» Entrez Gene Number: NP_001026850 View All» Gene Symbol:

• RUNX3

• AML2

• CBFA3

• PEBP2A3
  View All» Alternate Names:
  • Runt-related transcription factor 3

  • Acute myeloid leukemia 2 protein

  • Core-binding factor subunit alpha-3

  • CBF-alpha-3

  • Oncogene AML-2

  • Polyomavirus enhancer-binding protein 2 alpha C subunit

  • PEA2-alpha C

  • PEBP2-alpha C

  • SL3-3 enhancer factor 1 alpha C subunit

  • SL3/AKV core-binding factor alpha C subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.SUBUNIT STRUCTURE Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: The tyrosine phosphorylated form localizes to the cytoplasm. View All» Product Name: Anti-Runx3, clone R3-5G4 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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