货号：MABE157

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HOXD4 Antibody, clone 8E11.1 | MABE157 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~38 kDa observed. 28 kDa calculated. Observed molecular weight is ~38 kDa due to the proline-rich N-terminus of HOXD-4. (Phelan, M.L., Sadoul, R., Featherstone, M.S. (1994). Mol Cell Biol. 14(8):5066-5075.) View All» Immunogen: GST-tagged recombinant protein corresponding to human HOXD4. View All» Clone: 8E11.1 View All» Isotype: IgMκ View All» Background Information: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. It is reported that all Hox paralog group 4 members, A4, B4, C4, and D4, have similar effects on hematopoietic stem and progenitor self-renewal in vitro. It is shown that each paralog group 4 member both promotes proliferation and inhibits differentiation, thereby enabling the exponential expansion of hematopoietic progenitors from c-kit(+)/CD41(+) cell fractions of day 6 murine embryoid bodies. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. Predicted to react with Human based on immunogen design. View All» Control: Rat kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat kidney tissue lysate.Western Blot Analysis: A 1:1,2000 dilution of this antibody detected HOXD4 in 10 µg of rat kidney tissue lysate. View All» Purification Method: Purified by ion exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P09016 View All» Entrez Gene Number: NP_055436 View All» Gene Symbol:
  • HOXD4

  • HOX4B
    View All» Alternate Names:
    • Homeobox protein Hox-D4

    • Homeobox protein HHO.C13

    • Homeobox protein Hox-4B

    • Homeobox protein Hox-5.1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.SUBCELLULAR LOCATION: Nucleus. View All» Product Name: Anti-HOXD4, clone 8E11.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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