货号：MABE161

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-E2F3 clone TFE31 Antibody | MABE161 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 65 kDa observed View All» Immunogen: Recombinant protein corresponding to human E2F3. View All» Clone: TFE31 View All» Isotype: IgG1κ View All» Background Information: Transcription factor E2F3 is one protein in a family of E2F/DP transcription activators involved in cell cycle progression. E2F3 binds DNA using DP proteins in the E2 recognition site. E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F 3 is regulated by complex formation with Rb p110. The loss of this function could ultimately lead to oncogenic transformation and the inability to terminally differentiate. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Chromatin Immunoprecipitation Analysis: A represenative lot was used by an independent laboratory in ChIP. (Schlisio, S., et al. (2002). The EMBO Journal. 21(21):5775-5786.)Immunohistochemistry Analysis: A represenative lot was used by an independent laboratory in IH. (Denchi, E., et al. (2005). Mol Cell Biol. 25(7):2660–2672.) View All» Control: Daudi cell lysate View All» Quality Assurance: Evaluated by Western Blot in Daudi cell lysate.Western Blot Analysis: 1:5000 dilution of this antibody detected E2F3 on 10 µg of Daudi cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00716 View All» Entrez Gene Number: NP_001940 View All» Gene Symbol:

• E2F3

• E2F-3
  View All» Alternate Names:
  • E2F transcription factor 3

  • transcription factor E2F3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner.SUBUNIT STRUCTURE: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP. SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Belongs to the E2F/DP family. View All» Product Name: Anti-E2F3 clone TFE31 Antibody View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-132915.htm
      © Merck Millipore代理MABE161 Anti-E23 clone TFE31 (mouse monoclonal)，产品报价联系微信jinshanbio