货号：MABE176

品牌：Merck Millipore

规格：1EA

目录价：￥5141.24

市场价格：￥4370.05

会员价格：￥4112.99

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-5-hydroxymethylcytosine Antibody, clone AB3/63.3 | MABE176 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects 5-hydroxymethyl cytosine, but not 5-methylcytosine or unmethylated cytosine. View All» Molecular Weight: Deteccts 5-Hydroxymethylcytosine. View All» Immunogen: 5-Hydroxymethylcytosine conjugated to BSA View All» Clone: AB3/63.3 View All» Isotype: IgG2aκ View All» Background Information: 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base formed from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of iron-dependent oxygenases. Data suggests that every mammilian cell contains 5-hydroxymethylcytosine, but the levels vary depending on the cell type; data also suggests that levels of 5-hydroxymethylcytosine increases with age. The highest levels are found in neuronal cells of the central nervous system and certain mammalian tissues such as mouse Purkinje and granule neurons. Although the exact function has not been fully elucidated, studies suggest that 5-hydroxymethlcytosine may regulate gene expression or initiate DNA demethylation. View All» Species Reactivity: All View All» Species Reactivity Note: Non-species specific antibody against modified DNA. Expected to detect 5-hydroxymethylcytosine in all species. View All» Control: Unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA View All» Quality Assurance: Evaluated by Dot Blot in a panel of unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA.Dot Blot Analysis: 10 µg/mL and 1 µg/mL of this antibody detected 5-hydroxymethylcytosine in a panel of unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA. View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» Alternate Names:

• 5hmeC

• 5' hydroxymethyl cytosine

• 5'OH methyl cytosine

• 5'OHmeC

• 5hmc

• 5-hmC
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Dot Blot

  • Immunocytochemistry
    View All» Product Name: Anti-5-hydroxymethylcytosine, clone AB3/63.3 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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